Theoretical principles underlying optical stimulation of a channelrhodopsin-2 positive pyramidal neuron
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چکیده
منابع مشابه
Theoretical principles underlying optical stimulation of a channelrhodopsin-2 positive pyramidal neuron.
Optogenetics is an emerging field of neuromodulation that permits scaled, millisecond temporal control of the membrane dynamics of genetically targeted cells using light. Optogenetic technology has revolutionized neuroscience research; however, numerous biophysical questions remain on the optical and neuronal factors impacting the modulation of neural activity with photon-sensitive ion channels...
متن کاملTheoretical principles underlying 1 optical stimulation of a 2 channelrhodopsin - 2 positive 3 pyramidal neuron 4 5 6 7 8 9 10 11
34 Optogenetics is an emerging field of neuromodulation that permits scaled, 35 millisecond temporal control of the membrane dynamics of genetically targeted 36 cells using light. Optogenetic technology has revolutionized neuroscience 37 research; however, numerous biophysical questions remain on the optical and 38 neuronal factors impacting the modulation of neural activity with photon sensiti...
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Vertebrate hair cells are responsible for the high fidelity encoding of mechanical stimuli into trains of action potentials (spikes) in afferent neurons. Here, we generated a transgenic zebrafish line expressing Channelrhodopsin-2 (ChR2) under the control of the hair-cell specific myo6b promoter, in order to examine the role of the mechanoelectrical transduction (MET) channel in sensory encodin...
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Pyramidal neuron (PN) dendrites compartmentalize voltage signals and can generate local spikes, which has led to the proposal that their dendrites act as independent computational subunits within a multilayered processing scheme. However, when a PN is strongly activated, back-propagating action potentials (bAPs) sweeping outward from the soma synchronize dendritic membrane potentials many times...
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While functional imaging is widely used in studies of the brain, how well the hemodynamic signal represents the underlying neural activity is still unclear. And there is a debate on whether hemodynamic signal is more tightly related to synaptic activity or action potentials. This study intends to address these questions by examining neurovascular coupling driven by pyramidal cells in the motor ...
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ژورنال
عنوان ژورنال: Journal of Neurophysiology
سال: 2012
ISSN: 0022-3077,1522-1598
DOI: 10.1152/jn.00501.2011